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Compare leading GLP-1 weight loss programs and find the one that fits your goals and budget.
By the TreatmentMD editorial team
Why it's our #1 pick
By the TreatmentMD editorial team
Welludr. combines the lowest advertised price on this page with a rate locked in for life and unlimited clinician messaging, which is why it takes the top spot.
A program's rating follows its place on our list. Our editorial team sets the order, and the commission we earn affects it. How we rate
01What they are
GLP-1 receptor agonists mimic a hormone your body already makes. Semaglutide acts on the GLP-1 receptor alone; tirzepatide acts on GLP-1 and GIP receptors together. Both come as FDA-approved brands and as compounded versions from state-licensed pharmacies, typically at a lower monthly cost.
The 2024 to 2025 shortages are now resolved; compounded versions remain available through state-licensed (503A) pharmacies, prepared for an individual patient with a medical need the standard product doesn't meet.
02The evidence
In large clinical trials paired with lifestyle changes, Wegovy® (semaglutide) led to about 15% average weight loss over 68 weeks, and Zepbound® (tirzepatide) about 15% to 21% over 72 weeks, depending on the dose. These are averages, not guarantees, and weight regain is common after stopping treatment.
03Choosing
If your insurance covers brand-name medication, start with a program that handles the prior authorization. If you are paying cash, compare the flat monthly cost and what is included. The highlights on each card cover those points.
Provider review
Welludr. pairs compounded GLP-1 weight loss treatment with unlimited clinician messaging and a care coach, all managed online.
A short online health assessment is reviewed by a clinician licensed in your state, who decides whether treatment is right for you before any medication ships.
Medication ships free from a licensed Florida compounding pharmacy once a clinician approves you. Members get unlimited messaging with licensed clinicians, and a care coach who checks in every two weeks.
A month-to-month plan that renews every 21 days, or 3, 6 and 12-month plans paid up front. Stop a prepaid plan early and the months not yet started are refunded.
Provider review
Embody offers compounded semaglutide and tirzepatide at one price for every dose, prescribed online by licensed clinicians, with no membership fee.
A short online health questionnaire, reviewed by a licensed provider who decides whether treatment is appropriate.
Medication ships free, cold and overnight from licensed U.S. pharmacies; Embody says within two days of your prescription. It says its care team handles refills and dosing questions around the clock.
Month to month, or 3, 6 and 12-month plans paid up front for a lower rate. Cancel at least 72 hours before your next billing date.
Provider review
SnagRx keeps one price that never rises with your dose, with the online visit, the medication and shipping all included.
A short online intake; SnagRx says a licensed clinician reviews it within 24 hours.
Free shipping from licensed U.S. 503A compounding pharmacies, with tracking; SnagRx says prescriptions received before 2pm Central ship the same day. The care team handles refills and dosing questions through the patient portal.
Month to month, or 3, 6 and 12-month plans for a lower rate. Payments are final, except a refund for the unused part of a plan if a provider decides you no longer qualify.
Wegovy® and Zepbound® are FDA-approved for chronic weight management and have been extensively studied for safety and efficacy.
The most common side effects are nausea, vomiting, diarrhea and constipation, which usually ease over time.
They carry an FDA boxed warning for a risk of thyroid C-cell tumors, based on animal studies, and should not be used by people with a personal or family history of medullary thyroid carcinoma (MTC) or MEN2, or during pregnancy.
Other warnings include pancreatitis and gallbladder problems, and a higher risk of low blood sugar when combined with insulin or a sulfonylurea.
This is a high-level summary, not a complete list.
Compounded versions have not been reviewed by the FDA.
A licensed clinician should decide whether treatment is right for you.
In clinical trials paired with lifestyle changes, Wegovy® (semaglutide) led to about 15% average weight loss over 68 weeks, and Zepbound® (tirzepatide) about 15% to 21% over 72 weeks, depending on the dose.
These are averages, not guarantees.
Individual results vary based on factors like starting weight, adherence to treatment, diet, exercise, and overall health.
In a head-to-head study of adults with obesity (without type 2 diabetes), people on tirzepatide (Zepbound®) lost more on average, about 20% of their body weight, than those on semaglutide (Wegovy®), at about 14%, over 72 weeks.
Semaglutide is still very effective and widely used, and one of the top choices.
Tirzepatide is also sold as Mounjaro®, and semaglutide as Ozempic®, both approved for type 2 diabetes.
Sometimes, for brand-name medication, and usually only after a prior authorization that checks your body mass index and related conditions.
Compounded medication is almost never covered.
Several of the programs above will check your coverage before you pay for a consult.
Compare what the monthly price includes, whether the medication is brand-name or compounded, how quickly a licensed clinician reviews your intake, what support you get between refills, and the cancellation terms.
The highlights on each card above cover those points.
Telehealth programs review your health history online, often within a day, and ship the medication to your door, usually at a lower cash price.
An in-person clinic can examine you and run labs on site, which some patients prefer.
Both can be effective when provided by qualified healthcare professionals.
GLP-1 medications are typically prescribed as long-term treatments.
Weight regain is common after stopping treatment, so there is no set minimum.
How long you stay on treatment is a decision to make with your clinician.
Our #1 pick
The lowest advertised price on our list, with unlimited clinician messaging.
