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Compare semaglutide programs and find the one that fits your goals and budget.
By the TreatmentMD editorial team
Why it's our #1 pick
By the TreatmentMD editorial team
Welludr. combines the lowest advertised semaglutide price on this page, medication included, with unlimited clinician messaging and a care coach, which is why it takes the top spot.
A program's rating follows its place on our list. Our editorial team sets the order, and the commission we earn affects it. How we rate
01What it is
Semaglutide is the active ingredient in Wegovy®, which is FDA approved for weight management as a weekly injection and, since December 2025, a daily pill. Ozempic® and Rybelsus® contain it too, but are approved for type 2 diabetes.
Semaglutide also comes as compounded versions from state-licensed pharmacies, typically at a lower monthly cost. The 2024 to 2025 shortages are now resolved; compounded versions remain available through state-licensed (503A) pharmacies, prepared for an individual patient with a medical need the standard product doesn't meet.
02The evidence
In the main trial behind Wegovy®, people lost about 15% of their body weight over 68 weeks, compared with about 2% on a placebo. In adults with heart disease and excess weight, it also lowered the risk of heart attack, stroke and death from heart disease by 20%.
These results belong to Wegovy®. Compounded semaglutide has not been tested in trials.
03Choosing
Without insurance, Wegovy® costs $349 a month from its maker, and the pill $149 to $299, depending on the dose. Some insurance plans cover it after a prior authorization.
Compounded semaglutide starts at about $49 to $69 a month at our top three, with the medication included. Your dose rises every four weeks at first, so check that your price holds as it does.
Provider review
Welludr. pairs compounded semaglutide, as a weekly injection or a daily tablet, with unlimited clinician messaging and a care coach, all managed online.
A short online health assessment is reviewed by a clinician licensed in your state, who decides whether treatment is right for you before any medication ships.
Medication ships free from a licensed Florida compounding pharmacy once a clinician approves you. Members get unlimited messaging with licensed clinicians, and a care coach who checks in every two weeks.
A month-to-month plan that renews every 21 days, or 3, 6 and 12-month plans paid up front. Stop a prepaid plan early and the months not yet started are refunded.
Provider review
Embody offers compounded semaglutide at one price for every dose, with free coaching, free shipping and no membership fee.
A short online health questionnaire, reviewed by a licensed provider who decides whether treatment is appropriate.
Medication ships free, cold and overnight from licensed U.S. pharmacies; Embody says within two days of your prescription. It says its care team handles refills and dosing questions around the clock.
Month to month, or 3, 6 and 12-month plans paid up front for a lower rate. Cancel at least 72 hours before your next billing date.
Provider review
SnagRx offers compounded semaglutide at one all-in price for every dose, with the online visit, medication and free shipping included.
A short online intake; SnagRx says a licensed clinician reviews it within 24 hours.
Free shipping from licensed U.S. 503A compounding pharmacies, with tracking; SnagRx says prescriptions received before 2pm Central ship the same day. The care team handles refills and dosing questions through the patient portal.
Month to month, or 3, 6 and 12-month plans for a lower rate. Payments are final, except a refund for the unused part of a plan if a provider decides you no longer qualify.
Wegovy® is FDA approved for long-term weight management and has been extensively studied for safety and efficacy.
The most common side effects are nausea, diarrhea, vomiting and constipation, mostly while your dose is rising, and they usually ease over time.
It carries a boxed warning about thyroid tumors seen in animal studies, and it is not for anyone with a personal or family history of medullary thyroid cancer or MEN 2, or who is pregnant.
Other warnings include pancreatitis and gallbladder problems, and a higher risk of low blood sugar when combined with insulin or a sulfonylurea.
This is a high-level summary, not a complete list.
Compounded semaglutide has not been reviewed by the FDA for safety or effectiveness.
A licensed clinician should decide whether treatment is right for you.
In the main trial behind Wegovy®, people lost about 15% of their body weight on average over 68 weeks, compared with about 2% on a placebo.
On the higher 7.2 mg dose, approved in March 2026, people lost about 19% over 72 weeks, and on the Wegovy® pill about 14% over 64 weeks.
Your results depend on your dose, how long you stay on treatment and changes to diet and activity.
Without insurance, Wegovy® costs $349 a month from its maker, and new patients pay $199 for each of their first two fills through December 2026.
The Wegovy® pill costs $149 to $299 a month, depending on the dose.
Compounded semaglutide starts at about $49 to $69 a month at our top three programs, with the clinician and the medication included.
Some plans cover Wegovy® for weight loss, usually after a prior authorization that checks your body mass index and related conditions.
Medicare's GLP-1 Bridge program covers it for a $50 copay through December 2027, for people who qualify.
Compounded semaglutide is almost never covered.
Of the programs above, Ro has an insurance team that checks private plans and files the paperwork for you.
Wegovy® is made by Novo Nordisk and approved by the FDA, and it is the medication behind every study result on this page.
Compounded semaglutide is prepared by a state-licensed pharmacy for an individual patient.
It is not FDA approved, which means the FDA has not reviewed it for safety, quality or effectiveness.
It costs much less, which is why most programs on this list offer it.
Semaglutide is meant for long-term use.
In a follow-up to its main trial, people who stopped had regained about two-thirds of the weight they lost within a year.
How long you stay on treatment is a decision to make with your clinician.
Our #1 pick
The lowest advertised semaglutide price on our list, with unlimited clinician messaging.
