Guide
What is Foundayo™ (orforglipron)?
By the TreatmentMD editorial team
Key takeaways
- Foundayo™ is a once-a-day pill for weight loss that works on GLP-1, and you can take it with or without food.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
- In the main study, people on the top dose lost about 11% of their weight on average, against about 2% on a placebo.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources2The New England Journal of MedicineRandomized trial · 2025ATTAIN-1People lost 11.2% of their weight on the top dose, against 2.1% on placebo, over 72 weeks.3,127 people · 72 weeks. Adults with obesity, or overweight and a weight-related condition, without diabetes. Funded by Eli Lilly.Orforglipron, an oral small-molecule GLP-1 receptor agonist for obesity treatment. Wharton S, et al., 2025.Read the study All sources
- Paying cash, it starts at $149 a month, and Medicare's GLP-1 Bridge covers it for $50 for people who qualify.3Eli Lilly and CompanySourceLillyDirect. Foundayo™ (orforglipron) self-pay prices. Checked October 6, 2026.Open the source All sources4Centers for Medicare and Medicaid ServicesSourceCMS. Medicare GLP-1 Bridge: information for providers. Checked October 6, 2026.Open the source All sources
By the TreatmentMD editorial team
Foundayo™ is one of the newest ways to take a GLP-1: a small daily pill, with no needles and no fasting routine.5Eli Lilly and CompanySourceLilly. How to take Foundayo™. Checked October 6, 2026.Open the source All sources
Here's a friendly tour of what it is, how it compares with the shots, and who it may fit.
01The basics
What is Foundayo™?
Foundayo™ is the brand name for orforglipron, a once-a-day pill for weight loss made by Eli Lilly.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
The FDA approved it on April 1, 2026, and it reached U.S. pharmacies a week later.6U.S. Food and Drug AdministrationSourceFDA. Drugs@FDA approval histories for Wegovy® tablets (December 22, 2025), Foundayo™ (April 1, 2026) and tirzepatide products.Open the source All sources7Eli Lilly and CompanySourceEli Lilly and Company. Foundayo™ (orforglipron), Lilly's new oral GLP-1 pill for weight loss, now available in the U.S. April 9, 2026.Open the source All sources
Like the weekly shots, it works on GLP-1, a hormone your gut releases after you eat, so you feel full sooner and less hungry.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
It's a small molecule rather than a peptide like semaglutide or tirzepatide, and you take it with or without food.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
New to all this? What is GLP-1? covers the basics of the whole family.
02How it works
How does Foundayo™ help you lose weight?
It turns down hunger and helps you feel full sooner.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
Foundayo™ works on the parts of your brain that handle appetite, so you tend to eat less. It also slows how fast your stomach empties, mostly in the early weeks.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
Most of the weight people lose is fat rather than muscle.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
Taken daily, it reaches a steady level in your body after about a week.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
03Who it's for
Who can take Foundayo™?
It's for adults with obesity, or with overweight plus a weight-related condition, like high blood pressure.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
In the studies, that meant a BMI of 30 or more, or 27 or more with a condition.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
It's approved for weight loss, not for type 2 diabetes, though people with diabetes took part in the studies too.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
It's for adults only, and you don't need to have diabetes. Your clinician will help you decide whether it's a good fit.
04Taking it
How do you take Foundayo™?
One tablet a day, swallowed whole, with or without food.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
There's no fasting or water rule, so you can take it at whatever time suits your day.5Eli Lilly and CompanySourceLilly. How to take Foundayo™. Checked October 6, 2026.Open the source All sources
You start low and step up, with at least 30 days on each dose:1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
First month: 0.8 mg
A starting dose that gets your body used to the medicine.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
Second month: 2.5 mg
Your first step up, after at least 30 days.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
Third month: 5.5 mg
The first of the doses people took in the main study.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
Then, if you need more: 9, 14.5 or 17.2 mg
With at least 30 days on each, the top dose comes about five months in at the earliest.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
Each strength comes in its own bottle of 30 tablets. Keep it at room temperature, no fridge needed.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
If you miss a dose, just take it when you remember, as long as it isn't two in one day.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
If you take the pill for birth control, your clinician may suggest a backup method for 30 days after you start and after each step up.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
05Results
How much weight do people lose on Foundayo™?
In the main study, people on the top dose lost about 11% of their weight over 72 weeks, about 17 months. On a placebo, they lost about 2%.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources2The New England Journal of MedicineRandomized trial · 2025ATTAIN-1People lost 11.2% of their weight on the top dose, against 2.1% on placebo, over 72 weeks.3,127 people · 72 weeks. Adults with obesity, or overweight and a weight-related condition, without diabetes. Funded by Eli Lilly.Orforglipron, an oral small-molecule GLP-1 receptor agonist for obesity treatment. Wharton S, et al., 2025.Read the study All sources
About 7 in 10 lost at least 5% of their weight, and about half lost at least 10%.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
The lower doses helped too, with about 7% to 8% on average.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
In a second study of people with type 2 diabetes, the top dose led to about 10%.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
Everyone in these studies also had diet and activity coaching, and results varied from person to person.
06Compared with the others
How does Foundayo™ compare with the shots and the Wegovy® pill?
On average, the weekly shots lead to more weight loss. In separate studies, people lost about 15% on the Wegovy® shot and about 15% to 21% on Zepbound®.8The New England Journal of MedicineRandomized trial · 2021STEP 1Mean body weight fell 14.9 percent on semaglutide against 2.4 percent on placebo over 68 weeks.1,961 people · 68 weeks. Adults with BMI 30 or above, or 27 or above with a weight-related comorbidity, without diabetes.Once-weekly semaglutide in adults with overweight or obesity. Wilding JPH, et al., 2021.Read the study All sources9The New England Journal of MedicineRandomized trial · 2022SURMOUNT-1Mean body weight fell 20.9 percent at the 15 mg dose against 3.1 percent on placebo over 72 weeks.2,539 people · 72 weeks. Adults with BMI 30 or above, or 27 or above with at least one weight-related complication, without diabetes.Tirzepatide once weekly for the treatment of obesity. Jastreboff AM, et al., 2022.Read the study All sources
No study has compared Foundayo™ with the Wegovy® pill directly. In its own study, people lost about 14% on the Wegovy® pill.10The New England Journal of MedicineRandomized trial · 2025OASIS 4People lost 13.6% of their weight on the Wegovy pill, against 2.2% on placebo, over 64 weeks.307 people · 64 weeks. Adults with obesity, or overweight and a weight-related condition, without diabetes. Funded by Novo Nordisk.Oral semaglutide at a dose of 25 mg in adults with overweight or obesity. Wharton S, et al., 2025.Read the study All sources
Where Foundayo™ shines is how easily it fits into your day: no needles, no fasting and no fridge.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources5Eli Lilly and CompanySourceLilly. How to take Foundayo™. Checked October 6, 2026.Open the source All sources
Here's how pills compare with shots.
07Who it may fit
Is Foundayo™ a good fit for you?
It could suit you if:
You'd rather skip needles
It's a pill, so there are no shots or pens to learn.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
You travel a lot
No fridge needed, so it goes where you go.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
Your mornings are busy
No fasting or water rules, so any time of day works.5Eli Lilly and CompanySourceLilly. How to take Foundayo™. Checked October 6, 2026.Open the source All sources
You want to keep weight off after a shot
In one study, people who switched from a weekly shot kept about three-quarters of the weight they'd lost a year later.11Nature MedicineRandomized trial · 2026ATTAIN-MAINTAINA year after switching from a weekly shot to orforglipron, people kept about three-quarters of the weight they had lost, against under half on placebo.376 people · 52 weeks. Adults who had lost weight on 72 weeks of tirzepatide or semaglutide shots. Funded by Eli Lilly.Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial. Aronne LJ, et al., 2026.Read the study All sources
If you want the most weight loss on average, a weekly shot may suit you better. Your clinician can help you choose.
08Side effects
What are the side effects like?
The most common ones are stomach-related, like nausea, constipation, diarrhea or vomiting.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
They're most common while the dose is rising, and ease over time.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
In the studies, fewer than 1 in 10 people stopped because of side effects.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
A few habits help:
Eat smaller meals
Try splitting three meals into four or more smaller ones, and stop eating when you feel full.12Eli Lilly and CompanySourceLilly. Foundayo™: side effects, and tips that may help. Checked October 6, 2026.Open the source All sources
Go easy on fatty foods
Rich foods like butter or cheese can be harder to handle, and bland ones like toast, crackers or rice are easier.12Eli Lilly and CompanySourceLilly. Foundayo™: side effects, and tips that may help. Checked October 6, 2026.Open the source All sources
Keep your muscles busy
Protein at every meal and strength training a few times a week help you keep muscle.13Obesity PillarsSourceMozaffarian D, Agarwal M, Aggarwal M, et al. Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society. Obesity Pillars. 2025;15:100181.Open the source All sources
Keep your clinician in the loop
Tell them how you're feeling, and about every medicine you take.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
09Cost
How much does Foundayo™ cost?
Paying cash, Foundayo™ runs from $149 to $349 a month by dose, with some doses reduced through December 31, 2026.3Eli Lilly and CompanySourceLillyDirect. Foundayo™ (orforglipron) self-pay prices. Checked October 6, 2026.Open the source All sources
With commercial insurance that covers it, Lilly's savings card can bring it down to as little as $25 a month.14Eli Lilly and CompanySourceLilly. Coverage and savings for Foundayo™. Checked October 6, 2026.Open the source All sources
Coverage is growing, too: CVS Caremark plans began covering it in June 2026.15Eli Lilly and CompanySourceEli Lilly and Company. Foundayo and Zepbound now covered for millions of Americans. May 28, 2026.Open the source All sources
With Medicare, the GLP-1 Bridge covers Foundayo™ for $50 a month through 2027, for people who qualify.4Centers for Medicare and Medicaid ServicesSourceCMS. Medicare GLP-1 Bridge: information for providers. Checked October 6, 2026.Open the source All sources
You can fill it at your local pharmacy or through LillyDirect, Lilly's own pharmacy.7Eli Lilly and CompanySourceEli Lilly and Company. Foundayo™ (orforglipron), Lilly's new oral GLP-1 pill for weight loss, now available in the U.S. April 9, 2026.Open the source All sources3Eli Lilly and CompanySourceLillyDirect. Foundayo™ (orforglipron) self-pay prices. Checked October 6, 2026.Open the source All sources
10Getting started
How do you get Foundayo™?
You'll need a prescription. Many people start with an online program: you answer some health questions, and a licensed clinician decides whether it fits.
We look at clinicians, pharmacies and pricing when we rank programs, so you can start with a shortlist.
Frequently asked questions.
Is Foundayo™ the same as the Wegovy® pill?
No. The Wegovy® pill is semaglutide, taken on an empty stomach with a little water and a 30-minute wait.
Foundayo™ is a different medicine you can take with or without food.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources16U.S. Food and Drug AdministrationSourceFDA prescribing information for Wegovy® tablets: Dosage and Administration.All sources
Is Foundayo™ a pill version of Zepbound®?
No. Both are made by Lilly, but Zepbound® is tirzepatide, a weekly shot, and Foundayo™ is orforglipron, a different medicine.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources6U.S. Food and Drug AdministrationSourceFDA. Drugs@FDA approval histories for Wegovy® tablets (December 22, 2025), Foundayo™ (April 1, 2026) and tirzepatide products.Open the source All sources
Foundayo™ is new. How well studied is it?
It was approved in 2026, but its two main studies alone included about 4,700 adults, followed for 72 weeks each.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
Will I need to take it long term?
Most likely.
It's approved to help you lose weight and keep it off over the long term, so it's worth planning the long run with your clinician.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
Can I take Foundayo™ with other medicines?
Usually, yes.
A few medicines change how much of it your body takes in, so just tell your clinician everything you take.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
Does it matter what time of day I take it?
No, any time of day works.
Taking it at the same time each day can help you remember.5Eli Lilly and CompanySourceLilly. How to take Foundayo™. Checked October 6, 2026.Open the source All sources
Can older adults take Foundayo™?
Yes.
In the studies, people 65 and older did about as well as younger adults, with no overall differences in safety.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
What if I'm planning a pregnancy?
Talk to your clinician before you try.
If you become pregnant while taking it, let them know right away, and they'll talk you through stopping.1U.S. Food and Drug AdministrationSourceFDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.All sources
The bottom line
Foundayo™ is a once-a-day GLP-1 pill you can take with or without food, at any time of day.
In its main study, people on the top dose lost about 11% of their weight on average.
A licensed clinician can tell you whether it fits, and our ranking can help you choose a program.
By the TreatmentMD editorial team
Medical disclaimerThis content is for informational purposes only and is not medical advice. Always consult a qualified healthcare provider before starting any weight-loss program or medication. Individual results may vary.
Sources
- 1FDA prescribing information for Foundayo™ (orforglipron) tablets, revised July 2026: Indications and Usage; Dosage and Administration; Use in Specific Populations; Clinical Pharmacology; Adverse Reactions; Clinical Studies; Storage.
- 2Wharton S, Aronne LJ, Stefanski A, et al. Orforglipron, an oral small-molecule GLP-1 receptor agonist for obesity treatment. N Engl J Med. 2025;393(18):1796-1806. doi.org
- 3LillyDirect. Foundayo™ (orforglipron) self-pay prices. Checked October 6, 2026. lilly.com
- 4CMS. Medicare GLP-1 Bridge: information for providers. Checked October 6, 2026. cms.gov
- 5Lilly. How to take Foundayo™. Checked October 6, 2026. lilly.com
- 6FDA. Drugs@FDA approval histories for Wegovy® tablets (December 22, 2025), Foundayo™ (April 1, 2026) and tirzepatide products. fda.gov
- 7Eli Lilly and Company. Foundayo™ (orforglipron), Lilly's new oral GLP-1 pill for weight loss, now available in the U.S. April 9, 2026. lilly.mediaroom.com
- 8Wilding JPH, Batterham RL, Calanna S, et al. Once-weekly semaglutide in adults with overweight or obesity. N Engl J Med. 2021;384(11):989-1002. doi.org
- 9Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide once weekly for the treatment of obesity. N Engl J Med. 2022;387(3):205-216. doi.org
- 10Wharton S, Lingvay I, Bogdanski P, et al. Oral semaglutide at a dose of 25 mg in adults with overweight or obesity. N Engl J Med. 2025;393(11):1077-1087. doi.org
- 11Aronne LJ, Horn DB, le Roux CW, et al. Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial. Nat Med. 2026;32(7):2679-2687. doi.org
- 12Lilly. Foundayo™: side effects, and tips that may help. Checked October 6, 2026. lilly.com
- 13Mozaffarian D, Agarwal M, Aggarwal M, et al. Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society. Obesity Pillars. 2025;15:100181. nih.gov
- 14Lilly. Coverage and savings for Foundayo™. Checked October 6, 2026. lilly.com
- 15Eli Lilly and Company. Foundayo and Zepbound now covered for millions of Americans. May 28, 2026. biospace.com
- 16FDA prescribing information for Wegovy® tablets: Dosage and Administration.
Product information
- Zepbound® (tirzepatide) is a prescription-only injectable medication FDA-approved for chronic weight management in adults with obesity, or adults with overweight who have at least one weight-related medical condition. It is also approved for the treatment of moderate to severe obstructive sleep apnea in adults with obesity, and should be used in combination with a reduced-calorie diet and increased physical activity.
- Ozempic® (semaglutide) is a prescription-only injectable medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of type 2 diabetes. It is not FDA-approved for weight loss; however, weight reduction has been observed in some individuals with type 2 diabetes using the medication.
- Mounjaro® (tirzepatide) is a prescription-only injectable medication FDA-approved for the treatment of type 2 diabetes. It is not FDA-approved for weight loss; however, weight reduction has been observed in some individuals using the medication.
- Wegovy® (semaglutide) is a prescription-only injectable medication FDA-approved for chronic weight management in adults with obesity, or adults with at least one weight-related medical condition, when used alongside a reduced-calorie diet and increased physical activity.
- All medications require a medical evaluation and prescription from a licensed healthcare provider. Individual results may vary.
Important safety information
- Compounded semaglutide and tirzepatide are prepared by state-licensed pharmacies and are not FDA approved. The FDA does not review their safety, effectiveness or quality, and clinical trial results for brand-name drugs do not carry over to them.
- Semaglutide and tirzepatide carry a boxed warning for a risk of thyroid C-cell tumors, based on animal studies, and are not for anyone with a personal or family history of medullary thyroid carcinoma (MTC) or MEN2, or who is pregnant. Other warnings include pancreatitis, gallbladder problems, and a higher risk of low blood sugar when combined with insulin or a sulfonylurea. The most common side effects are digestive, such as nausea, vomiting, diarrhea and constipation.
- This is a high-level summary, not a complete list. A licensed clinician will review your health history to decide whether a GLP-1 medication is right for you.
